منابع مشابه
Cell senescence: role in aging and age-related diseases.
Cell senescence is one of the major paradigms of aging research. It started with the demonstration by L. Hayflick of the limited number of divisions by normal, nontransformed cells, not shown by transformed malignant cells, this processes being largely regulated by the telomere-telomerase system. A complete renewal of this discipline came from the demonstration that cells can enter senescence a...
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regulation of the age-related decline of pancreatic b-cell replication. In the above-cited article, one funding agency was not identified in the Acknowledgments. The information, " O.Z. is a New York Stem Cell Foundation–Druckenmiller Fellow, " should have been included in the Acknowledgments.
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Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca(2+) dynamics in mouse β-cells. We show that these changes are likely to be accounted for by impaired mitochondrial function and to involve phospholip...
متن کاملCognition in aging and age-related disease
Chapter Synopsis Aging can have diverse effects on cognitive function. For many people, aging is associated with relatively little cognitive decline ( “healthy” or “successful” aging). For some, memory declines significantly with age, but does not prevent performance of daily activities ( “mild cognitive impairment”). For others, aging is associated with severe cognitive deficits that impede th...
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The increase in the prevalence of obesity represents a worldwide phenomenon in all age groups and is pathologically and genetically correlated with several metabolic and cardiovascular diseases, representing the most frequent age-related diseases. Obesity superimposed on aging drastically increases chronic low-grade inflammation (inflammaging), which is an important link between obesity, insuli...
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ژورنال
عنوان ژورنال: Aging
سال: 2021
ISSN: 1945-4589
DOI: 10.18632/aging.202593